Figure S8 from Vγ9Vδ2 T Cells Express an Antitumor Profile Associated with Anti–PD-(L)1 Responses and Activation Defects Restored by Anti-BTN3A in Triple-Negative Breast Cancer

Key Points

Vγ9Vδ2 T cells exhibit a skewed differentiation profile associated with early effector memory phenotype.
In untreated triple-negative breast cancer patients, defects in T cell activation were observed.
Restoration of T cell activation was achieved through anti-BTN3A treatment.
The study highlights potential therapeutic implications for enhancing immune responses in cancer.

Analysis of Vγ9Vδ2 T cells shows an antitumor profile linked to anti-PD-L1 responses, suggesting potential therapeutic targets.

Vg9Vd2 T cells display skewed differentiation profiles towards an early effector memory phenotype in untreated TNBC (related to Figure 3).

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Fattori et al. (2025) studied this question.

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