Figure S4 from Vγ9Vδ2 T Cells Express an Antitumor Profile Associated with Anti–PD-(L)1 Responses and Activation Defects Restored by Anti-BTN3A in Triple-Negative Breast Cancer

Stéphane Fattori; Laurent Gorvel; Marie-Sarah Rouvière; Samuel Granjeaud; Amira Ben Amara; Manon Richaud; Nicolas Boucherit; Carole Tarpin; Jihane Pakradouni; Julien Hédou; Grégoire Bellan; Brice Gaudillière; Emmanuelle Charafe‐Jauffret; Gilles Houvenaeghel; Éric Lambaudie; François Bertucci; Jean‐Jacques Fournié; Anthony Gonçalvès; Philippe Rochigneux; Anne-Sophie Chrétien; Daniel Olive

doi:10.1158/2326-6066.30255250

Key Points

Vγ9Vδ2 T cells are linked with enhanced survival in patients with triple-negative breast cancer (TNBC).
Patients exhibiting an antitumor profile among Vγ9Vδ2 T cells show better outcomes with anti-PD-(L)1 treatments.
Anti-BTN3A therapy helps restore activation in Vγ9Vδ2 T cells, addressing their functional defects.
These findings emphasize the potential of immunotherapy to improve treatment strategies in TNBC.

Implication

Observational analysis reveals improved survival linked to Vγ9Vδ2 T cells in triple-negative breast cancer patients, suggesting immunotherapy options.

Abstract

Vγ9Vδ2 T cells are associated with better survival in TNBC (related to Figure 1).

Discussion

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Cite This Study

Fattori et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21a83 https://doi.org/10.1158/2326-6066.30255250

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Figure S4 from Vγ9Vδ2 T Cells Express an Antitumor Profile Associated with Anti–PD-(L)1 Responses and Activation Defects Restored by Anti-BTN3A in Triple-Negative Breast Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S4 from Vγ9Vδ2 T Cells Express an Antitumor Profile Associated with Anti–PD-(L)1 Responses and Activation Defects Restored by Anti-BTN3A in Triple-Negative Breast Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

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