Table S13 from Vγ9Vδ2 T Cells Express an Antitumor Profile Associated with Anti–PD-(L)1 Responses and Activation Defects Restored by Anti-BTN3A in Triple-Negative Breast Cancer

Stéphane Fattori; Laurent Gorvel; Marie-Sarah Rouvière; Samuel Granjeaud; Amira Ben Amara; Manon Richaud; Nicolas Boucherit; Carole Tarpin; Jihane Pakradouni; Julien Hédou; Grégoire Bellan; Brice Gaudillière; Emmanuelle Charafe‐Jauffret; Gilles Houvenaeghel; Éric Lambaudie; François Bertucci; Jean‐Jacques Fournié; Anthony Gonçalvès; Philippe Rochigneux; Anne-Sophie Chrétien; Daniel Olive

doi:10.1158/2326-6066.30255214

Key Points

Vg9Vd2 T cells exhibit an antitumor profile linked to responses against anti-PD-(L)1 therapies.
LASSO analysis indicates that activation defects in these T cells can be restored by anti-BTN3A treatment.
Triple-negative breast cancer presents challenges, but manipulating Vg9Vd2 cells may enhance therapeutic outcomes.
Understanding these mechanisms could improve strategies for targeting immune responses in challenging cancer types.

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Implication

LASSO analysis reveals Vg9Vd2 T cells' antitumor profile in triple-negative breast cancer, suggesting that anti-BTN3A could restore activation defects.

Abstract

LASSO analysis of Vg9Vd2 T cells outputs, related to Figure 5

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Fattori et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21a27 https://doi.org/10.1158/2326-6066.30255214

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Table S13 from Vγ9Vδ2 T Cells Express an Antitumor Profile Associated with Anti–PD-(L)1 Responses and Activation Defects Restored by Anti-BTN3A in Triple-Negative Breast Cancer

Key Points

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Implication

Abstract

Discussion

Cite This Study

Table S13 from Vγ9Vδ2 T Cells Express an Antitumor Profile Associated with Anti–PD-(L)1 Responses and Activation Defects Restored by Anti-BTN3A in Triple-Negative Breast Cancer

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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