Table S10 from Vγ9Vδ2 T Cells Express an Antitumor Profile Associated with Anti–PD-(L)1 Responses and Activation Defects Restored by Anti-BTN3A in Triple-Negative Breast Cancer

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Key Points

Vγ9Vδ2 T cells exhibit an antitumor profile, enhancing immune responses in triple-negative breast cancer.
Activation defects in Vγ9Vδ2 T cells were restored with anti-BTN3A, increasing their efficacy against tumors.
Interactome analysis identifies significant connections between Vγ9Vδ2 T cells and immune checkpoint inhibitors.
The findings highlight the potential for combination therapies targeting both anti-PD-(L)1 and BTN3A pathways.

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Analysis reveals antitumor profile of Vγ9Vδ2 T cells in triple-negative breast cancer, suggesting recovery of activation defects with anti-BTN3A.

LIANA interactome analysis of Vg9Vd2 T cells outputs, related to Figure 4

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Fattori et al. (2025) studied this question.

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