Table S8 from Vγ9Vδ2 T Cells Express an Antitumor Profile Associated with Anti–PD-(L)1 Responses and Activation Defects Restored by Anti-BTN3A in Triple-Negative Breast Cancer

Key Points

Vγ9Vδ2 T cells show an antitumor profile associated with improved responses to anti–PD-(L)1 therapies.
Analysis of gene characteristics highlights activation defects in these T cells that can be restored by anti-BTN3A treatment.
Observational analysis reveals the role of Vγ9Vδ2 T cells in the context of triple-negative breast cancer treatments.
Findings support the potential therapeutic implications of targeting Vγ9Vδ2 T cells in breast cancer management.

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Analysis finds Vγ9Vδ2 T cells exhibit an antitumor profile in triple-negative breast cancer, indicating activation defects can be restored.

Gene characteristics of Vg9Vd2 T cell subsets, related to Figure 3

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Fattori et al. (2025) studied this question.

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