Table S12 from Vγ9Vδ2 T Cells Express an Antitumor Profile Associated with Anti–PD-(L)1 Responses and Activation Defects Restored by Anti-BTN3A in Triple-Negative Breast Cancer

Stéphane Fattori; Laurent Gorvel; Marie-Sarah Rouvière; Samuel Granjeaud; Amira Ben Amara; Manon Richaud; Nicolas Boucherit; Carole Tarpin; Jihane Pakradouni; Julien Hédou; Grégoire Bellan; Brice Gaudillière; Emmanuelle Charafe‐Jauffret; Gilles Houvenaeghel; Éric Lambaudie; François Bertucci; Jean‐Jacques Fournié; Anthony Gonçalvès; Philippe Rochigneux; Anne-Sophie Chrétien; Daniel Olive

doi:10.1158/2326-6066.30255217

Key Points

Vγ9Vδ2 T cells display an antitumor profile in response to therapy, indicating potential for immunotherapy.
GSEA showed significant changes in gene expression between pre- and post-antibody treatment T cells.
This analysis involved differentially expressed genes in breast tumors, suggesting a mechanism for treatment response.
Findings imply that restoring activation defects in T cells could enhance treatment efficacy in triple-negative breast cancer.

Implication

GSEA reveals differential gene expression in Vγ9Vδ2 T cells, highlighting anti-PD-(L)1 implications and activation defects.

Abstract

GSEA outputs based on the differentially expressed genes between pre–αPD–1 versus post–αPD–1 Vg9Vd2 T cells in primary breast tumors, related to Figure 5

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Cite This Study

Fattori et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21a96 https://doi.org/10.1158/2326-6066.30255217

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Table S12 from Vγ9Vδ2 T Cells Express an Antitumor Profile Associated with Anti–PD-(L)1 Responses and Activation Defects Restored by Anti-BTN3A in Triple-Negative Breast Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Table S12 from Vγ9Vδ2 T Cells Express an Antitumor Profile Associated with Anti–PD-(L)1 Responses and Activation Defects Restored by Anti-BTN3A in Triple-Negative Breast Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

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