Table S7 from Vγ9Vδ2 T Cells Express an Antitumor Profile Associated with Anti–PD-(L)1 Responses and Activation Defects Restored by Anti-BTN3A in Triple-Negative Breast Cancer

Stéphane Fattori; Laurent Gorvel; Marie-Sarah Rouvière; Samuel Granjeaud; Amira Ben Amara; Manon Richaud; Nicolas Boucherit; Carole Tarpin; Jihane Pakradouni; Julien Hédou; Grégoire Bellan; Brice Gaudillière; Emmanuelle Charafe‐Jauffret; Gilles Houvenaeghel; Éric Lambaudie; François Bertucci; Jean‐Jacques Fournié; Anthony Gonçalvès; Philippe Rochigneux; Anne-Sophie Chrétien; Daniel Olive

doi:10.1158/2326-6066.30255193

Key Points

Vγ9Vδ2 T cells exhibit an antitumor profile, which is associated with enhanced anti–PD-(L)1 responses in triple-negative breast cancer.
GSEA outputs indicate significant differences in gene expression between Vγ9Vδ2 T cells and other T cell subsets in primary breast tumors.
Anti-BTN3A treatment has the potential to restore activation defects in Vγ9Vδ2 T cells, suggesting therapeutic avenues for improved responses.
These findings underline the importance of T cell activation states in shaping immune responses in triple-negative breast cancer patients.

Implication

GSEA analysis reveals Vγ9Vδ2 T cells express an antitumor profile, highlighting anti–PD-(L)1 responses and activation defects.

Abstract

GSEA outputs based on the differentially expressed genes between Vg9Vd2 T cells versus abCD8 TemraTex, abCD8 Tem and Vd1 T cell in primary breast tumors, related to Figure 2

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Fattori et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21a56 https://doi.org/10.1158/2326-6066.30255193

View at Publisher

Ask AI

Bookmark

Share

Table S7 from Vγ9Vδ2 T Cells Express an Antitumor Profile Associated with Anti–PD-(L)1 Responses and Activation Defects Restored by Anti-BTN3A in Triple-Negative Breast Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Table S7 from Vγ9Vδ2 T Cells Express an Antitumor Profile Associated with Anti–PD-(L)1 Responses and Activation Defects Restored by Anti-BTN3A in Triple-Negative Breast Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading