Table S11 from Vγ9Vδ2 T Cells Express an Antitumor Profile Associated with Anti–PD-(L)1 Responses and Activation Defects Restored by Anti-BTN3A in Triple-Negative Breast Cancer

This is a Quantitative Study study.

Key Points

vg9vd2 t cells exhibit an antitumor profile, enhancing potential treatment strategies in triple-negative breast cancer.
Differential gene expression analysis compares pre- and post-anti-pd-1 vg9vd2 t cells, underlining the impact of PD-1 blockade.
The study explores restoration of activation defects in vg9vd2 t cells with anti-btn3a therapy, providing insights into immunotherapy.
Findings indicate that manipulation of vg9vd2 t cells may improve treatment outcomes in breast cancer by targeting specific gene expressions.

Analysis reveals differential gene expression in vg9vd2 t cells pre and post anti-pd-1 treatment, suggesting anti-btn3a may restore activation.

Differentially expressed genes between Pre–αPD–1 versus Post–αPD–1 Vg9Vd2 T cells in primary breast tumors, related to Figure 5

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Fattori et al. (2025) studied this question.

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