Figure S7 from Vγ9Vδ2 T Cells Express an Antitumor Profile Associated with Anti–PD-(L)1 Responses and Activation Defects Restored by Anti-BTN3A in Triple-Negative Breast Cancer

Stéphane Fattori; Laurent Gorvel; Marie-Sarah Rouvière; Samuel Granjeaud; Amira Ben Amara; Manon Richaud; Nicolas Boucherit; Carole Tarpin; Jihane Pakradouni; Julien Hédou; Grégoire Bellan; Brice Gaudillière; Emmanuelle Charafe‐Jauffret; Gilles Houvenaeghel; Éric Lambaudie; François Bertucci; Jean‐Jacques Fournié; Anthony Gonçalvès; Philippe Rochigneux; Anne-Sophie Chrétien; Daniel Olive

doi:10.1158/2326-6066.30255241

Key Points

Vg9Vd2 T cells show an early effector memory phenotype in triple-negative breast cancer patients.
PD-1 blockade therapy affects the differentiation of Vg9Vd2 T cells, highlighting their potential role in treatment.
Activation defects in Vg9Vd2 T cells may be restored by targeting BTN3A, indicating a new therapeutic avenue.
Single-cell RNA sequencing (scRNA-seq) provides insights into T cell profiles related to cancer treatment.

Implication

Analysis shows Vg9Vd2 T cells exhibit altered differentiation profiles in TNBC, suggesting implications for anti-PD-1 treatments.

Abstract

Vg9Vd2 T cells display skewed differentiation profiles towards an early effector memory phenotype in untreated and PD–1 blockade–treated TNBC (scRNA–seq, related to Figure 3).

Discussion

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Cite This Study

Fattori et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21a95 https://doi.org/10.1158/2326-6066.30255241

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Figure S7 from Vγ9Vδ2 T Cells Express an Antitumor Profile Associated with Anti–PD-(L)1 Responses and Activation Defects Restored by Anti-BTN3A in Triple-Negative Breast Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S7 from Vγ9Vδ2 T Cells Express an Antitumor Profile Associated with Anti–PD-(L)1 Responses and Activation Defects Restored by Anti-BTN3A in Triple-Negative Breast Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

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