Supplementary Figure S1 from PI3K/Akt Signaling Pathway Regulates CD155 Expression Involved in Resistance to Cancer Immunotherapy

Q: What type of study is this?

This is a In Vitro Study study.

Katsushige Kawase; Shusuke Kawashima; Tatsuya Nishi; Takashi Inozume; Takao Morinaga; Masahito Kawazu; Toyoyuki Hanazawa; Yosuke Togashi

doi:10.1158/2326-6066.30255061

October 1, 2025

Supplementary Figure S1 from PI3K/Akt Signaling Pathway Regulates CD155 Expression Involved in Resistance to Cancer Immunotherapy

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Key Points

The study reveals that the PI3K/Akt signaling pathway regulates CD155 expression, impacting resistance to cancer immunotherapy.
In vitro data from CRISPR screening highlights the role of Dyrk1a-deleted cells in modulating this resistance mechanism.
Observational analysis includes additional experiments using CRISPR technology to better understand genetic impacts on treatment outcomes.
Findings suggest potential areas for targeting therapies to overcome resistance, though further exploration is needed in clinical contexts.

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Implication

In vitro analysis uncovers how the PI3K/Akt signaling pathway influences CD155 expression, suggesting implications for cancer immunotherapy resistance.

Abstract

Additional in vitro data related CRISPR screening and Dyrk1a-deleted cells

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Cite This Study

Kawase et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21ae0 https://doi.org/10.1158/2326-6066.30255061

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Supplementary Figure S1 from PI3K/Akt Signaling Pathway Regulates CD155 Expression Involved in Resistance to Cancer Immunotherapy

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S1 from PI3K/Akt Signaling Pathway Regulates CD155 Expression Involved in Resistance to Cancer Immunotherapy

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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