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October 1, 2025

Figure S5 from Regulatory T Cells Poise the Myeloid Landscape after Chemotherapy in Lung Tumors

Eléonore Weber-Delacroix Marylou Panouillot Marie Laviron François Lanthiez Tristan Philippe Sandrine Barthélémy Solène Fastenackels Armanda Casrouge Benoı̂t L. Salomon Ingrid Sassoon Jérémy Baudhuin Ilaria Onorati Marianne Kambouchner Nahla Cucherousset Christophe Combadière Boris Duchemann Marie‐Caroline Dieu‐Nosjean Alexandre Boissonnas

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Key Points

TNFR2 blockade significantly improves the chemotherapy response in lung tumors, aiding treatment efficacy.
Key evidence includes the enhancement of myeloid landscape adjustment upon chemotherapy after TNFR2 blockade.
Assessment utilized experimental study methodologies to observe effects on regulatory T cells in the tumor environment.
These findings suggest that manipulating immune cell types may optimize chemotherapy outcomes in lung cancer patients.

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Implication

Analysis shows TNFR2 blockade enhances chemotherapy efficacy in lung tumors, indicating a role of regulatory T cells in immune modulation.

Abstract

TNFR2 blockade improves chemotherapy response

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Cite This Study

Weber-Delacroix et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21aff https://doi.org/10.1158/2326-6066.30254972

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Synapse has enriched 8 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S6 from Regulatory T Cells Poise the Myeloid Landscape after Chemotherapy in Lung Tumors2025
2Figure S2 from Regulatory T Cells Poise the Myeloid Landscape after Chemotherapy in Lung Tumors2025
3Figure S4 from Regulatory T Cells Poise the Myeloid Landscape after Chemotherapy in Lung Tumors2025
4Figure S1 from Regulatory T Cells Poise the Myeloid Landscape after Chemotherapy in Lung Tumors2025
5Data from Regulatory T Cells Poise the Myeloid Landscape after Chemotherapy in Lung Tumors2025
6Video S1 from Regulatory T Cells Poise the Myeloid Landscape after Chemotherapy in Lung Tumors2025
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8Table S5 from CD25high Effector Regulatory T Cells Hamper Responses to PD-1 Blockade in Triple-Negative Breast Cancer2024