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October 1, 2025

Video S2 from Regulatory T Cells Poise the Myeloid Landscape after Chemotherapy in Lung Tumors

Eléonore Weber-Delacroix Marylou Panouillot Marie Laviron François Lanthiez Tristan Philippe Sandrine Barthélémy Solène Fastenackels Armanda Casrouge Benoı̂t L. Salomon Ingrid Sassoon Jérémy Baudhuin Ilaria Onorati Marianne Kambouchner Nahla Cucherousset Christophe Combadière Boris Duchemann Marie‐Caroline Dieu‐Nosjean Alexandre Boissonnas

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Key Points

Tregs significantly alter the myeloid landscape in lung tumors following chemotherapy, impacting tumor behavior.
In vivo imaging demonstrated Tregs crawling within tumor nodules, indicating their active role in the tumor environment.
Chemotherapy appears to reorganize the myeloid landscape due to the regulatory effects of Tregs on myeloid cells.
The findings may influence future therapeutic strategies targeting the immune landscape in lung cancer post-chemotherapy.

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Implication

In vivo imaging reveals Tregs impacting the myeloid landscape after chemotherapy in lung tumors, suggesting therapeutic implications.

Abstract

In vivo imaging of the lung shows Tregs (TdTomato+, red) crawling within the tumor nodules. Tumor vasculature (gray) was detected using Blue Evans.

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Cite This Study

Weber-Delacroix et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21b00 https://doi.org/10.1158/2326-6066.30254945

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Keep reading

Synapse has enriched 8 closely related papers on similar clinical questions. Consider them for comparative context:

1Video S1 from Regulatory T Cells Poise the Myeloid Landscape after Chemotherapy in Lung Tumors2025
2Figure S2 from Regulatory T Cells Poise the Myeloid Landscape after Chemotherapy in Lung Tumors2025
3Figure S1 from Regulatory T Cells Poise the Myeloid Landscape after Chemotherapy in Lung Tumors2025
4Figure S5 from Regulatory T Cells Poise the Myeloid Landscape after Chemotherapy in Lung Tumors2025
5Data from Regulatory T Cells Poise the Myeloid Landscape after Chemotherapy in Lung Tumors2025
6Figure S6 from Regulatory T Cells Poise the Myeloid Landscape after Chemotherapy in Lung Tumors2025
7Figure S4 from Regulatory T Cells Poise the Myeloid Landscape after Chemotherapy in Lung Tumors2025
8Abstract 6860: Fluorescent tracking reveals that radiation therapy influences the migration and plasticity of Tregs within the tumor microenvironment2024