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October 2, 2025Angewandte ChemieOpen Access

Amide and Thioester Synthesis Via Oxidative Coupling of Alcohols with Amines or Thiols Using Alcohol Dehydrogenases

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This research demonstrates oxidative coupling to synthesize amides and thioesters from alcohols, suggesting new biocatalytic approaches.

Conversion rates for linear aliphatic alcohols reached up to 90%, revealing high efficiency in amide synthesis.
The method achieved over 99% conversion and 87% isolated yield for N-methyl amides on a preparative scale.
Engineering of the Aa-ADH variant enabled enhanced activity toward longer-chain substrates, indicating potential for broader applications.
This work highlights enzyme promiscuity as a valuable strategy for biocatalytic synthesis, potentially reducing reliance on traditional methods.

Damian et al. (2025) studied this question.

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