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This is a Experimental Study study.

Amide and Thioester Synthesis Via Oxidative Coupling of Alcohols with Amines or Thiols Using Alcohol Dehydrogenases

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This research demonstrates biocatalytic synthesis of amides and thioesters in a greener manner, highlighting enzyme promiscuity in novel pathways.

Oxidative coupling using alcohol dehydrogenases produces amides and thioesters efficiently, maintaining high conversion rates.
Primary and secondary amides were synthesized with more than 90% conversion, employing pH-optimized conditions and specific alcohol types.
The method showcased preparative-scale success, achieving over 99% conversion and high yield of N-methyl amide using engineered alcohol dehydrogenases.
Protein engineering of alcohol dehydrogenases expanded their activity to longer-chain amines and thiols, enhancing synthetic capabilities.

Damian et al. (2025) studied this question.

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This research demonstrates biocatalytic synthesis of amides and thioesters in a greener manner, highlighting enzyme promiscuity in novel pathways.