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October 2, 2025European Journal of ChemistryOpen Access

New green HPLC and TLC methods for the determination of dapagliflozin, metformin hydrochloride, and its two official impurities, melamine and cyanoguanidine, in their quaternary mixture

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Authors

NINashwa K. IbrahimEAEglal Abdelhamid Abd El Aleem El AleemWAWalaa Gamal Abuelazem

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Overview

Novel green hplc and tlc methods quantify dapagliflozin and metformin in pharmaceutical formulations, indicating eco-friendliness.

Key Points

  • The green hplc method accurately measures dapagliflozin and metformin in a quaternary mixture.
  • Retention times for dapagliflozin, metformin, melamine, and cyanoguanidine were 5.75, 2.06, 2.49, and 3.01 min, respectively.
  • The proposed methods demonstrated good linearity with concentration ranges tailored for each component.
  • Statistical analysis revealed no significant differences when comparing to a published hplc method for the same compounds.

Cite This Study

Ibrahim et al. (2025) studied this question.

synapsesocial.com/papers/68de84b65b556a9128e1b4e0https://doi.org/10.5155/eurjchem.16.3.302-310.2688
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Also Consider

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  1. 1Quantitative Determination of Metformin Hydrochloride in Tablet Formulation Containing Croscarmellose Sodium as Disintegrant by HPLC and UV Spectrophotometry2012 · 53 citations