Case report highlights incidental findings of 18F-PR04.MZ uptake in a bone lesion, indicating potential diagnostic implications in Parkinson's disease.
We report a 68-year-old man with clinically established Parkinson’s disease who underwent PET/CT imaging of the dopamine transporter (DAT) with the novel radiopharmaceutical 18 F-PR04.MZ. The scan showed the expected reduced striatal uptake, but also revealed unexpected, focal accumulation of the radiotracer in the right frontal bone. Corresponding CT identified a well-circumscribed, hypodense lesion, compatible with fibrous dysplasia. A follow-up CT performed 4 years later confirmed lesion stability.
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Damián et al. (2025) studied this question.
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