October 2, 2025eLifeOpen Access

Observational activation of anterior cingulate cortical neurons coordinates hippocampal replay in social learning

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The activation of anterior cingulate cortex neurons is reactivated during observation, influencing behavior.
Observation-induced activities in ACC are correlated with hippocampal place cell activities during spatial tasks.
ACC neuron activities predict hippocampal replay during subsequent self-navigation tasks, indicating neural interactions.
Errors during trials reduce ACC response, revealing a link between ACC activity and decision-making accuracy.

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Observational analysis shows ACC neuron activation influences hippocampal replay in rats, suggesting neural coordination in learning.

Mou et al. (2025) studied this question.

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