Open-label randomized clinical trial examines tolvaptan and fluid restriction in hyponatremia, suggesting potential comparative benefits.
Journal Article Accepted manuscript Response to Letter to the Editor from Sumi and Tominaga: "Tolvaptan versus fluid restriction in moderate-profound hyponatremia: An open-label randomized clinical trial" Get access Annabelle M Warren, MBBS(Hons), Annabelle M Warren, MBBS(Hons) Austin Health Department of Endocrinology, Heidelberg, VIC, AustraliaUniversity of Melbourne Department of Medicine, Austin Health, Heidelberg, VIC, AustraliaAlfred Health Department of Endocrinology and Diabetes, Melbourne, VIC, Australia Corresponding author: Dr. Annabelle M Warren, Austin Health Department of Endocrinology, 145 Studley Road, Heidelberg, 3084, Victoria, Australia, Email: [email protected] https://orcid.org/0000-0002-7287-6162 Search for other works by this author on: Oxford Academic Google Scholar Mathis Grossmann, PhD, Mathis Grossmann, PhD Austin Health Department of Endocrinology, Heidelberg, VIC, AustraliaUniversity of Melbourne Department of Medicine, Austin Health, Heidelberg, VIC, Australia https://orcid.org/0000-0001-8261-3457 Search for other works by this author on: Oxford Academic Google Scholar Rudolf Hoermann, PhD, Rudolf Hoermann, PhD University of Melbourne Department of Medicine, Austin Health, Heidelberg, VIC, Australia https://orcid.org/0000-0002-1326-4270 Search for other works by this author on: Oxford Academic Google Scholar Rose Lin, MD, Rose Lin, MD Austin Health Department of Endocrinology, Heidelberg, VIC, AustraliaUniversity of Melbourne Department of Medicine, Austin Health, Heidelberg, VIC, Australia Search for other works by this author on: Oxford Academic Google Scholar Jeffrey D Zajac, PhD, Jeffrey D Zajac, PhD Austin Health Department of Endocrinology, Heidelberg, VIC, AustraliaUniversity of Melbourne Department of Medicine, Austin Health, Heidelberg, VIC, Australia https://orcid.org/0000-0003-3933-5708 Search for other works by this author on: Oxford Academic Google Scholar Nicholas Russell, PhD Nicholas Russell, PhD Austin Health Department of Endocrinology, Heidelberg, VIC, AustraliaUniversity of Melbourne Department of Medicine, Austin Health, Heidelberg, VIC, Australia https://orcid.org/0000-0001-5596-6601 Search for other works by this author on: Oxford Academic Google Scholar The Journal of Clinical Endocrinology & Metabolism, dgaf538, https://doi.org/10.1210/clinem/dgaf538 Published: 01 October 2025 Article history Received: 16 September 2025 Accepted: 25 September 2025 Published: 01 October 2025
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