A case highlights the false-positive potential of 18F-FDG PET findings in multiple myeloma, suggesting careful interpretation of CT scans.
¹⁸F-FDG focal uptake in bone is always concerning, especially in patients with a history of cancer. We report a case of increasing hypermetabolic activity of a maxillary bone lesion in a patient with a history of multiple myeloma that was managed with definitive treatment. A targeted CT scan revealed that the abnormal ¹⁸F-FDG uptake was fibrous dysplasia. Vigilant interpretation is required for focal osseous activity on PET/CT in patients with a history of cancer to avoid false-positive readings.
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Manzil et al. (2025) studied this question.
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