Efficacy of Ozone Therapy and Low Level Laser Therapy (LLLT) in Managing Oral Lesions: A Systematic Review and Meta-Analysis

Background: In contrast to corticosteroids, which have long-term adverse effects, low level laser therapy and ozone therapy are now the most effective treatment techniques for oral lesions. Objective: To systematically review the existing scientific literature in providing a comprehensive, quantitative analysis to evaluate better efficacy between laser and ozone therapy on management of oral lesions. Methods: The review complied with PRISMA 2020 requirements and was recorded in PROSPERO under the CRD42024532899 number. Studies assessing the impact of both on different oral lesions were found by searching electronic databases. Results: The meta-analysis incorporated five studies, while the qualitative synthesis included eight randomized controlled trials (RCTs). Every study that was included had a moderate to low chance of being biased. Despite the fact that both laser and ozone therapy were beneficial on their own, a meta-analysis revealed that the laser group experienced a greater reduction in pain, while the ozone therapy group experienced a greater improvement in lesion severity, or something comparable, in both groups ( P > 0.05). There was no evidence of publication bias in the funnel plot. Conclusion: Although ozone and laser therapy were similarly beneficial, the mean reduction in pain intensity was higher with laser therapy.