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October 3, 2025

Electroacupuncture ameliorates learning and memory impairment by inhibiting inflammation and promoting synaptic plasticity via inhibition of the NF-KB/NLRP3 signaling pathway in cerebral ischemic rats.

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Authors

CHChuchu HuangTongde Hospital of Zhejiang ProvinceGPGuoyuan PanTongde Hospital of Zhejiang ProvinceDLDan LüTongde Hospital of Zhejiang Province

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Implication

Experimental research shows electroacupuncture enhances cognitive recovery in rats, suggesting it may inhibit inflammation and support neuroplasticity.

Key Points

  • Electroacupuncture significantly reduces learning and memory impairments in cerebral ischemic rats, improving their overall cognitive function.
  • Neural function scores and escape latency in the electroacupuncture group were notably lower compared to those in control groups, indicating enhanced recovery.
  • Histological analyses revealed decreased brain injury markers and increased dendritic structure and synaptic proteins after electroacupuncture treatment.
  • The findings suggest electroacupuncture may inhibit the NF-KB/NLRP3 signaling pathway, regulating inflammation and enhancing synaptic plasticity.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68e02f34f0e39f13e7fa2036https://doi.org/10.14670/hh-18-997
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Electroacupuncture alleviates cerebral ischemia injury by promoting microglial polarization and inhibiting inflammation in MCAO rats.2026
  2. 2Electroacupuncture Attenuates Cerebral Ischemia/Reperfusion Injury and Enhances Neurological Recovery via Modulating Ferroptosis-Associated Proteins2026
  3. 3Electroacupuncture improves the learning and memory abilities of rats with PSCI by attenuating the TLR4/NF-κB/NLRP3 signaling pathway on the hippocampal microglia2024 · 11 citations
  4. 4Electroacupuncture pretreatment ameliorates cerebral ischemia/reperfusion injury by inhibiting the miR-124/NF-κB/Fas signaling pathway2025 · 6 citations
  5. 5Electroacupuncture Ameliorates Cerebral Ischemia-Reperfusion Injury by Inhibiting Pyroptosis through the Sirtuin-1 Pathway2024 · 1 citations