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October 3, 2025Current Drug Targets

Cytokeratin 8 as a Novel Therapeutic Target in Type 2 Diabetes Mellitus: Suppression of Hepatic Glycogen Synthesis via IRS1/PI3K/Akt/GSK3β Signaling

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Authors

MSMingzhu SunXLXiuli LiJSJin Sun

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Overview

Functional analysis reveals cytokeratin 8 modulates glycogen synthesis via IRS1/PI3K/Akt/GSK3β signaling in T2DM.

Key Points

  • Cytokeratin 8 (CK8) was identified as a negative regulator of liver glycogen synthesis in type 2 diabetes.
  • CK8 was significantly upregulated while insulin signaling pathways and glycogen synthesis were suppressed.
  • Knockdown of CK8 restored glycogen synthesis, indicating its crucial role in T2DM pathophysiology.
  • Inhibiting CK8 may provide a new therapeutic strategy for enhancing insulin action and glycogen storage.

Cite This Study

Sun et al. (2025) studied this question.

synapsesocial.com/papers/68e02f3cf0e39f13e7fa24b3https://doi.org/10.2174/0113894501394500250903095958
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ANGPTL8 regulates glucose metabolism in gestational diabetes mellitus mice, and proteomic analysis reveals the PI3K/Akt pathway plays its role in insulin-resistance HepG2 cells2026
  2. 2A DYRK inhibitor ameliorates glucose homeostasis and increases incretin-producing cells in diabetic mice2026
  3. 38569 Defining Cell-Intrinsic Defects In Hepatic Insulin Resistance In Type 2 Diabetes Using A Human iPS Cell-Derived Disease-In-A-Dish Model2024
  4. 4PDE4B regulating NOX3/JNK/ALKBH5-mediated GCK methylation in accelerating the development of type 2 diabetes combined with fatty liver2024
  5. 5Circulating Angiopoietin-like Protein 8 Is Independently Associated With Fasting Plasma Glucose and Type 2 Diabetes Mellitus2014 · 57 citations