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October 3, 2025Current Pharmaceutical Design

Mechanisms, Mediators, and Pharmacological Approaches Targeting Brain Cholesterol Transport in Alzheimer’s Disease

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Authors

MUMartina UgolottiBPBianca PapottiATAlessandro Trentini

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Overview

This review highlights the role of cholesterol transport in Alzheimer's disease, suggesting new pharmacological interventions for CNS homeostasis.

Key Points

  • Impaired cholesterol transport is linked to the pathogenesis of Alzheimer's disease, emphasizing its role in neurodegeneration.
  • The review identifies key molecular players, including apolipoprotein E, affecting cholesterol transport and their relation to Alzheimer's disease.
  • Recent preclinical studies unveil promising pharmacological interventions aimed at modulating cholesterol homeostasis in the CNS.
  • Cholesterol transport regulation in the brain could provide novel directions for therapeutic development in neurodegenerative diseases.

Cite This Study

Ugolotti et al. (2025) studied this question.

synapsesocial.com/papers/68e02f3cf0e39f13e7fa24c1https://doi.org/10.2174/0113816128411158250909151734
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Targeting Brain Cholesterol Homeostasis in Alzheimer's Disease: Mechanisms and Therapeutic Perspectives2026
  2. 2The Intersection of Cerebral Cholesterol Metabolism and Alzheimer's Disease: Mechanisms and Therapeutic Prospects2024 · 15 citations
  3. 3Cholesterol metabolism in neurodegenerative diseases: mechanisms and therapeutic advances2026
  4. 4Abnormal brain cholesterol homeostasis in Alzheimer’s disease—a targeted metabolomic and transcriptomic study2021 · 160 citations
  5. 5Cholesterol at the Center of Alzheimer’s Disease: A Unifying Hypothesis on the Pathogenic Mechanism2026