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June 14, 2026Journal of NeurochemistryOpen Access

Targeting Brain Cholesterol Homeostasis in Alzheimer's Disease: Mechanisms and Therapeutic Perspectives

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Authors

MRMyuri RuthirakuhanATAmeer Y. TahaWSWalter Swardfager

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Overview

Review explores how disruptions in cholesterol balance contribute to Alzheimer's disease and therapeutic strategies to restore it.

Key Points

  • This review aims to outline the role of brain cholesterol homeostasis in Alzheimer's disease and potential therapeutic interventions.
  • Synthesis of current evidence regarding the impacts of cholesterol on brain health and Alzheimer's progression.
  • Review of mechanisms linking cholesterol dysregulation to amyloid processing, tau pathology, and neuroinflammation.
  • Discussion of therapeutic strategies to restore cholesterol balance in the context of Alzheimer's disease.
  • Altered brain cholesterol homeostasis is linked to increased amyloid-β production and tau-related vulnerabilities.
  • Disruptions in cholesterol regulation are shown to impair glial-neuronal lipid coupling and membrane stability.
  • Therapeutic strategies targeting cholesterol balance may complement existing amyloid- and tau-focused interventions.

Cite This Study

Ruthirakuhan et al. (2026) studied this question.

synapsesocial.com/papers/6a2e46dbb1cc60ccdea8b715https://doi.org/10.1111/jnc.70492
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