Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
October 3, 2025Open Access

Protein-Induced Membrane Strain Drives Supercomplex Formation

View Full Paper
Ask AI
Bookmark
Share

Authors

MPMaximilian C. PöverleinAJAlexander JussupowHKHyunho Kim

Discussion

Loading...

Member takes

Overview

Molecular simulations reveal supercomplex assembly reduces membrane strain, suggesting thermodynamic benefits.

Key Points

  • Assembly of the I/III2 supercomplex reduces strain in mitochondrial membranes and alters local membrane thickness.
  • Supercomplex formation leads to the accumulation of cardiolipin and quinone around specific regions.
  • Molecular simulations and cryo-electron microscopy were used to study supercomplex dynamics in detail.
  • Findings suggest molecular crowding and strain effects could drive supercomplex formation and enhance flux.

Cite This Study

Pöverlein et al. (2025) studied this question.

synapsesocial.com/papers/68e02f3cf0e39f13e7fa277fhttps://doi.org/10.7554/elife.102104.2
View Full Paper
Ask AI
Bookmark
Share