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February 25, 2026eLifeOpen Access

Protein-induced membrane strain drives supercomplex formation

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Authors

MPMaximilian C. PöverleinAJAlexander JussupowHKHyunho Kim

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Overview

Large-scale simulations reveal how membrane strain promotes supercomplex assembly, enhancing mitochondrial function.

Key Points

  • The aim is to understand how supercomplex formation in mitochondrial membranes reduces molecular strain and its functional implications.
  • Combined large-scale atomistic and coarse-grained molecular simulations
  • Analysis of cryo-electron microscopic data
  • Statistical and kinetic modeling
  • Formation of the I/III 2 supercomplex reduces molecular strain in the inner mitochondrial membrane
  • Changes in local membrane thickness and accumulation of cardiolipin and quinone around the supercomplex
  • Altered global motion of individual electron transport chain proteins with potential functional consequences

Cite This Study

Pöverlein et al. (2026) studied this question.

synapsesocial.com/papers/699e912ef5123be5ed04e908https://doi.org/10.7554/elife.102104.4
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