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April 23, 2026Nature CommunicationsOpen Access

Mitochondrial respirasome-like supercomplexes support metabolic flexibility in yeast

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Authors

MEMazzen H. EldeebZCZoe CosnerACAndreas Carlström

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Overview

Engineered yeast reveals supercomplexes improve electron transfer and metabolite flexibility in mitochondria.

Key Points

  • This research aims to clarify the roles of mitochondrial supercomplexes in respiratory flexibility in yeast.
  • Engineered a yeast strain with a covalently-linked supercomplex
  • Examined respiratory activities and substrate interactions
  • Analyzed the effects on NADH-driven respiration
  • The engineered strain shows robust respiratory activity
  • Covalently-linked supercomplex impacts NADH-driven respiration
  • Specific interactions enhance metabolic flexibility and electron flux

Cite This Study

Eldeeb et al. (2026) studied this question.

synapsesocial.com/papers/69e9baa885696592c86ecc8ehttps://doi.org/10.1038/s41467-026-72228-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Unveiling the role of yeast cytochrome c isoforms in the assembly of mitochondrial supercomplexes and the control of respiratory chain rate2024
  2. 2Protein-Induced Membrane Strain Drives Supercomplex Formation2024 · 1 citations
  3. 3Protein-induced membrane strain drives supercomplex formation2026
  4. 4The complexities of respiratory chain biogenesis and maintenance in yeast mitochondria2026
  5. 5Protein-Induced Membrane Strain Drives Supercomplex Formation2025