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October 3, 2025Acta Haematologica

Establishment and Evaluation of Prognostic Prediction Model for Diffuse Large B-cell Lymphoma Patients Based on International Prognostic Index and FAT4, TP53 Mutation

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Authors

LSLi ShaoDonghua UniversityZKZhen KouPeople's Hospital of Xinjiang Uygur Autonomous RegionARAbulaiti RenaguliPeople's Hospital of Xinjiang Uygur Autonomous Region

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Implication

Retrospective analysis identifies key prognostic factors in diffuse large B-cell lymphoma, suggesting enhanced model value by integrating genetic mutations.

Key Points

  • The study shows that integrating FAT4 and TP53 mutations improves prognostic accuracy in diffuse large B-cell lymphoma.
  • Independent prognostic factors for progression-free survival and overall survival were analyzed using multivariate COX modeling.
  • Receiver operating characteristic curves confirmed the predictive performance of the new FAT4-TP53-IPI model over traditional assessments.
  • Validation through bootstrapping reinforces the model's reliability, suggesting potential for better patient outcome predictions.

Cite This Study

Shao et al. (2025) studied this question.

synapsesocial.com/papers/68e02f40f0e39f13e7fa28achttps://doi.org/10.1159/000548543
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Also Consider

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  1. 1Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray2003 · 4,318 citations
  2. 2Identification of FAT4 as a positive prognostic biomarker in DLBCL by comprehensive genomic analysis2023 · 8 citations
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