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October 3, 2025Open Access

Global dynamics of antibiotic resistance: a modeling study of the spread of endemic and emerging resistance in E. coli

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Authors

EREve RahbéEVEugenio ValdanoDSDavid R. Smith

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Overview

Mechanistic modeling reveals transmission dynamics of E. coli resistance in different regions, suggesting key interventions.

Key Points

  • Emerging resistant clones of E. coli can be controlled by improving surveillance and data collection.
  • The study indicates transmission rates vary significantly, with Spain averaging 7.05x10-3 day-1 compared to 16.21x10-3 day-1 in Thailand.
  • Analyzing antibiotic prescriptions and human mobility highlights the drivers of antibiotic resistance spread, especially across borders.
  • The findings underline that reducing transmission and selection pressure are vital to mitigate antibiotic resistance on a global scale.

Cite This Study

Rahbé et al. (2025) studied this question.

synapsesocial.com/papers/68e02f46f0e39f13e7fa2ce7https://doi.org/10.1101/2025.09.25.25335519
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Also Consider

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  1. 1Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: systematic review and meta-analysis2010 · 2,042 citations
  2. 2The rise of carbapenem resistance in Europe: just the tip of the iceberg?2013 · 86 citations
  3. 3Contribution of mathematical modeling to the fight against bacterial antibiotic resistance2011 · 94 citations
  4. 4Emergence of Enterobacteriaceae producing extended-spectrum β-lactamases (ESBLs) in the community2005 · 795 citations
  5. 5The global prevalence and trend of human intestinal carriage of ESBL-producing Escherichia coli in the community2020 · 249 citations