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October 3, 2025Frontiers in OncologyOpen Access

Comparative study on bone mineral density in premenopausal patients with estrogen receptor-positive breast cancer in ASTRRA Study: a 5-year follow-up study

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Authors

ESEunju ShinSKSeung Il KimMPMin-ho Park

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Overview

Comparative analysis indicates ovarian function suppression may worsen bone mineral density in premenopausal patients with breast cancer.

Key Points

  • Ovarian function suppression led to a greater incidence of bone mineral density loss in patients at baseline, and there was a significant risk of deterioration.
  • The study included 522 premenopausal women, with a median age of 41.1 years, and evaluated bone mineral density changes over 5 years post-diagnosis.
  • Using dual-energy X-ray absorptiometry, bone density was measured at baseline and reevaluated 3 and 5 years after for changes across categories.
  • This study highlights the potential need for monitoring bone health in patients receiving ovarian function suppression for estrogen receptor-positive breast cancer.

Cite This Study

Shin et al. (2025) studied this question.

synapsesocial.com/papers/68e034f7f0e39f13e7fa31cdhttps://doi.org/10.3389/fonc.2025.1465256
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract PO2-12-06: Comparative Study on Bone Mineral Density in Premenopausal Patients with Estrogen Receptor-Positive Breast cancer in ASTRRA study: a 5-year follow-up study2024
  2. 2Abstract PO3-01-08: Interaction of Prior Chemotherapy and Addition of Ovarian Function Suppression on Menopausal Symptoms in Tamoxifen-Treated Breast Cancer Patient: A prospective, Observational study2024
  3. 3Abstract PS3-09-25: Factors Associated With Real-World Use of Ovarian Function Suppression Versus Tamoxifen Alone in Premenopausal Women With Early-Stage HR+/HER2- Breast Cancer2026
  4. 4Abstract PS1-03-18: Effects of cancer treatment on bone mineral density in premenopausal patients with early-stage breast cancer2026
  5. 5Effect of Tamoxifen on Lumbar Spine Bone Mineral Density in Postmenopausal Women After 5 Years1994 · 146 citations