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November 28, 1994Archives of Internal Medicine

Effect of Tamoxifen on Lumbar Spine Bone Mineral Density in Postmenopausal Women After 5 Years

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RLRichard R. Love

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Overview

Randomized trial reveals preserved lumbar spine bone mineral density in postmenopausal women receiving tamoxifen, suggesting long-term protection against osteoporotic fractures.

Key Points

  • Determine the five-year effects of adjuvant tamoxifen therapy on lumbar spine bone mineral density and bone turnover in postmenopausal women with early-stage breast cancer.
  • Follow-up study evaluating 62 postmenopausal women from an original two-year randomized placebo-controlled trial (N=140) who continued their assigned tamoxifen (N=30) or no-tamoxifen regimen (N=32) for five full years.
  • Assessed lumbar spine bone mineral density (BMD) and serum osteocalcin levels, adjusting for body mass index, exercise, and calcium supplementation.
  • Five-year lumbar spine BMD changes differed between groups (+0.8% with tamoxifen vs. -0.7% with placebo; P = .06), and the five-year mean BMD regression slopes differed significantly between arms (P = .0005).
  • Serum osteocalcin levels, comparable between arms at baseline, were significantly lower in tamoxifen-treated subjects at five years (P = .0005).

Cite This Study

Richard R. Love (1994) studied this question.

synapsesocial.com/papers/6aaa3f80cea203025eb43e6bhttps://doi.org/10.1001/archinte.1994.00420220081009
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  1. 1Effects of Tamoxifen on Cardiovascular Risk Factors in Postmenopausal Women After 5 Years of Treatment1994 · 286 citations
  2. 2Comparative study on bone mineral density in premenopausal patients with estrogen receptor-positive breast cancer in ASTRRA Study: a 5-year follow-up study2025
  3. 3Abstract PS1-03-18: Effects of cancer treatment on bone mineral density in premenopausal patients with early-stage breast cancer2026
  4. 4The influence of tamoxifen in vivo on the main natural anticoagulants and fibrinolysis1993 · 47 citations
  5. 5Effect of low-dose tamoxifen on benign gynecological and breast conditions in a phase III trial in non-invasive breast cancer2025 · 1 citations