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October 3, 2025Clinical and Experimental PediatricsOpen Access

Less invasive surfactant administration versus intubationsurfactant- extubation: a single-center retrospective study

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Authors

JCJithin CSANA. NalinaASA. Shashidhar

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Overview

Retrospective study shows less invasive surfactant administration reduces intubation needs in preterm infants with RDS, suggesting improved outcomes.

Key Points

  • LISA significantly reduced the need for intubation and mechanical ventilation within 72 hours compared to InSurE.
  • The LISA group had an intubation rate of 18% versus 64% in the InSurE group, with a relative risk of 0.28.
  • This retrospective observational study spanned five years, involving preterm neonates with RDS at 24-34 weeks' gestation.
  • LISA demonstrated benefits in reducing invasive ventilation duration, although no significant differences were observed in secondary outcomes.

Cite This Study

CS et al. (2025) studied this question.

synapsesocial.com/papers/68e034f7f0e39f13e7fa337chttps://doi.org/10.3345/cep.2025.00332
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Surfactant administration methods for premature newborns: LISA vs. INSURE comparative analysis2024 · 2 citations
  2. 2Less invasive surfactant administration versus intubation-surfactant-extubation in preterm infants: a retrospective study2024
  3. 3Minimally Invasive Surfactant Therapy Versus InSurE in Preterm Neonates of 28-34 Weeks of Gestation with Respiratory Distress Syndrome: A Randomised Controlled Trial2026
  4. 4Less invasive surfactant administration as a means to facilitate gentler transition for preterm infants? A narrative review2021 · 4 citations
  5. 5Non-Invasive Surfactant Administration in Preterm Infants2026 · 2 citations