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This is a Quantitative Study study.

October 3, 2025Clinical ChemistryOpen Access

B-090 High level of reproducibility of therapeutic monoclonal antibody detection on the EXENT® System

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The EXENT System demonstrated excellent intra- and inter-day precision in measuring m/z values for therapeutic monoclonal antibodies.
Inter-day mean m/z values for daratumumab, elotuzumab, and others were reported with a small variation from expected values, highlighting measurement reliability.
Mass spectrometry using the EXENT System can effectively distinguish between therapeutic monoclonal antibodies and M-proteins in clinical settings.
Setting interferent flags is crucial for accurate monoclonal gammopathy testing, considering the observed differences in m/z values.

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Assessment of the EXENT System shows high precision in measuring m/z values for t-mAbs, indicating effectiveness in monoclonal gammopathy testing.

Villar et al. (2025) studied this question.

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Assessment of the EXENT System shows high precision in measuring m/z values for t-mAbs, indicating effectiveness in monoclonal gammopathy testing.