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This is a Quantitative Study study.

October 3, 2025Clinical ChemistryOpen Access

B-270 Dilutions of lactate using the Roche Cobas assay as an aid to detection of ethylene glycol poisoning

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This analysis shows non-linearity in lactate responses with elevated glycolic acid levels, suggesting ethylene glycol poisoning.

Non-linearity in lactate dilution curves may indicate the presence of glycolic acid in ethylene glycol poisoning.
For spiked samples with 10 or 20 mmol/L glycolic acid, significant shifts in dilution curves were observed.
Measurements were conducted using the Roche Cobas lactate assay with varying concentrations of lactate and glycolic acid.
The findings support the potential for using lactate non-linearity to aid in diagnosing ethylene glycol poisoning.

Stickle et al. (2025) studied this question.

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