October 3, 2025Clinical ChemistryOpen Access

B-092 Humoral Immune Response after Prime and Boost Vaccination against SARS-CoV-2: a Follow-up Study among Healthcare Workers

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Authors

HCHyun-Woo ChoiChonnam National University Hospital CJChae-Hyeon JeonChonnam National University Hospital SKSeung‐Ji KangChonnam National University

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Implication

Prospective cohort study evaluated immune responses in healthcare workers after prime and booster vaccinations against SARS-CoV-2, indicating varying efficacy.

Key Points

At 180 days post-prime vaccination, antibody titers decreased more in ChAdOx1 than BNT162b2 vaccinated individuals, suggesting differing durability of immune response.
After booster vaccination with BNT162b2, both groups showed significant increases in antibody titers, highlighting the effectiveness of the booster.
By 90 days after the booster, antibody levels in the ChAdOx1 group decreased more than those in the BNT162b2 group, indicating quicker decline in immune response.
The study emphasizes the necessity for ongoing evaluation of vaccination regimens to optimize immune protection against COVID-19.

Cite This Study

Choi et al. (2025) studied this question.

synapsesocial.com/papers/68e040e9a99c246f578b305d https://doi.org/10.1093/clinchem/hvaf086.490

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Implication

Prospective cohort study evaluated immune responses in healthcare workers after prime and booster vaccinations against SARS-CoV-2, indicating varying efficacy.

B-092 Humoral Immune Response after Prime and Boost Vaccination against SARS-CoV-2: a Follow-up Study among Healthcare Workers

Discussion

Member takes

Implication

Key Points

Cite This Study

B-092 Humoral Immune Response after Prime and Boost Vaccination against SARS-CoV-2: a Follow-up Study among Healthcare Workers

Discussion

Member takes

Implication

Key Points

Cite This Study

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Also Consider