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October 3, 2025Clinical Chemistry

A-024 Prognosis for Adverse Events in Suspected ACS Without MI, and Subgroups with or Without History of Incident and Previous MACE Using the Atellica IM High-Sensitivity Troponin I Assay

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Authors

JSJennifer SnyderSBSarah BethoneyRBRyan Butterfield

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Overview

Prospective analysis evaluated cTnI's ability to predict all-cause mortality and MACE among ACS patients, indicating potential risks ahead.

Key Points

  • Patients with cTnI above the 99th percentile experienced significantly higher rates of all-cause mortality and major adverse cardiac events after one year.
  • Among the primary analysis population, 39.5% with high cTnI levels faced ACM/MACE compared to 12.9% with lower levels; aHR was 1.85 at 365 days.
  • This observational analysis incorporated 2,064 adult patients suspected of acute coronary syndrome across 29 U.S. sites from 2014 to 2016.
  • Highlighting the importance of baseline cTnI levels, findings suggest that monitoring may help identify higher-risk patients for adverse outcomes.

Cite This Study

Snyder et al. (2025) studied this question.

synapsesocial.com/papers/68e040e9a99c246f578b3154https://doi.org/10.1093/clinchem/hvaf086.024
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