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October 3, 2025Frontiers in Molecular BiosciencesOpen Access

Expression levels of interleukin-17 and interferon-γ in peripheral blood and relationship with thyroid function in patients with Hashimoto’s thyroiditis

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Authors

ZHZhiyong HuangJZJiaming ZhangSCShiyi Chen

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Overview

Analysis reveals elevated interleukin-17 and interferon-gamma levels in Hashimoto’s thyroiditis patients, suggesting critical links to thyroid function and autoantibodies.

Key Points

  • Serum levels of interleukin-17 and interferon-gamma are significantly elevated in Hashimoto’s thyroiditis patients compared to healthy controls.
  • The study found positive correlations between interleukin-17 levels and thyroid parameters, indicating its relevance in thyroid autoimmune conditions.
  • The logistic regression model identified interleukin-17 and interferon-gamma as influencing factors for the occurrence of Hashimoto’s thyroiditis.
  • ROC curve analysis shows that both interleukin-17 and interferon-gamma can serve as valuable biomarkers for early diagnosis of Hashimoto’s thyroiditis.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68e040eda99c246f578b32cdhttps://doi.org/10.3389/fmolb.2025.1645736
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Association of the Altered Interleukin-17 and Interleukin-21 Serum Levels with the Occurrence of Autoimmune Thyroid Diseases2026
  2. 2The Involvement of miRNA-375, miRNA-451, and IL-6 in the Immunopathogenesis of Hashimoto's Thyroiditis and Its Implications2025
  3. 3Correlation between Interleukin-23, Autoantibodies and Thyroid Profile in a Sample of Iraqi Patients with Hashimoto’s Thyroiditis2024
  4. 4Evaluation of Pro- and Anti-inflammatory Cytokines IL-17 and IL-33 in Autoimmune Hyperthyroidism2025 · 1 citations
  5. 5Inflammatory protein expression patterns in Hashimoto’s thyroiditis: a cross-sectional observational study2026