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May 8, 2026Medical Journal of BabylonOpen Access

The Association of the Altered Interleukin-17 and Interleukin-21 Serum Levels with the Occurrence of Autoimmune Thyroid Diseases

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Authors

HHHadi Hussein HamadARAmir Hani Raziq

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Overview

Randomized trial investigates serum interleukin levels in autoimmune thyroid diseases, suggesting potential biomarkers for diagnosis.

Key Points

  • The study aims to explore the relationship between interleukin-17 and interleukin-21 serum levels and autoimmune thyroid diseases.
  • Compared serum levels of interleukins, thyroid hormones, and anti-TPO antibodies in 45 patients and 45 controls.
  • Utilized enzyme-linked immunosorbent assay for measuring serological parameters.
  • Statistical analysis included comparison of means and significance testing.
  • Patients showed significantly higher thyroid stimulating hormone levels (12.04 ± 2.76) compared to controls (1.87 ± 0.15), P = 0.003.
  • Mean serum concentration of anti-TPO antibodies was elevated in patients (259.08 ± 59.99) vs. controls (8.71 ± 1.23), P < 0.001.
  • Patients had significantly higher IL-17 (44.05 ± 5.89) and IL-21 levels (57.03 ± 24.02) than controls (29.43 ± 7.99, P = 0.04; 43.87 ± 18.48, P = 0.02).

Cite This Study

Hamad et al. (2026) studied this question.

synapsesocial.com/papers/69fd7f25bfa21ec5bbf078eehttps://doi.org/10.4103/mjbl.mjbl_376_23
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Also Consider

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  5. 5Effect of autoantibodies and cytokines on thyroid disorders in Thi-Qar2024