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October 3, 2025Therapeutic Drug Monitoring

Liquid Chromatography–Tandem Mass Spectrometry Method for Simultaneous Quantification of Four Endocannabinoids and Endocannabinoid-Like Substances in Plasma: Application in an HIV—Hepatitis C Virus Coinfected Population

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Authors

AGAlexandr GishEREqbal RadwanCRCamille Richeval

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Overview

Liquid chromatography-tandem mass spectrometry quantifies endocannabinoids in plasma, showing clinical relevance in HIV-hepatitis C co-infection.

Key Points

  • The method successfully quantified endocannabinoids in plasma samples, demonstrating robust analytical performance.
  • Lower limits of quantification were achieved at 0.1 mcg/L for AEA and 0.2 mcg/L for 2-AG/1-AG, with high linearity across measurements.
  • Liquid-liquid extraction combined with mass spectrometry enables precise measurement of bioactive compounds in clinical settings.
  • Standardized preanalytical processing is crucial, as delays significantly affect the concentrations of endocannabinoids in samples.

Cite This Study

Gish et al. (2025) studied this question.

synapsesocial.com/papers/68e040eda99c246f578b3308https://doi.org/10.1097/ftd.0000000000001397
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