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October 3, 2025Open Access

Modeling the Effects of Over and Under Doses Antibiotic Treatment to Bacterial Resistance in Presence of Immune System

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Authors

UMUzzwal Kumar MallickJAJawad AhmedKIK. R. Islam

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Overview

Mathematical model examines the impact of antibiotic underdosing and overdosing on bacterial resistance, highlighting immune system interactions.

Key Points

  • Higher antibiotic doses reduce sensitive bacteria but increase resistant strains, and suppress immune cell levels.
  • Underdosing antibiotics increases the risk of resistance through bacterial mutations and enhances infection persistence.
  • Overdosing weakens the immune system by disrupting beneficial microbes, complicating treatment efficacy.
  • The analytical model's validity includes stability assessments at equilibrium and characteristics related to state variables.

Cite This Study

Mallick et al. (2025) studied this question.

synapsesocial.com/papers/68e040f3a99c246f578b37bchttps://doi.org/10.48550/arxiv.2509.16687
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