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This is a Cohort Study study (also classified as: Quantitative Study).

Interleukin 6 as a key inflammatory predictor of gestational diabetes – clinical and biochemical evidence

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Observational analysis shows IL-6 levels predict insulin resistance in gestational diabetes, suggesting its potential as a diagnostic biomarker.

Elevated IL-6 levels are significantly associated with insulin resistance in women with gestational diabetes.
Women with gestational diabetes exhibited IL-6 levels of 25.35 ng/L compared to 11.02 ng/L in controls, p<0.001.
Correlation and regression analyses were performed to assess the relationship between IL-6 and metabolic parameters.
Incorporating IL-6 measurement may enhance GDM screening protocols, improving diagnostic accuracy.

Hadi et al. (2025) studied this question.

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Observational analysis shows IL-6 levels predict insulin resistance in gestational diabetes, suggesting its potential as a diagnostic biomarker.