What question did this study set out to answer?

This research investigates the relationship between inflammatory cytokines, adipokines, and C-peptide with glycemic status in women with gestational diabetes.

April 1, 2026CureusOpen Access

Association Between Insulin Resistance Markers and Immunological Markers in Gestational Diabetes Mellitus

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Authors

VTVandana TiwaryJawaharlal Institute of Post Graduate Medical Education and Research MMMonisha MJawaharlal Institute of Post Graduate Medical Education and Research RRRamesh RJawaharlal Institute of Post Graduate Medical Education and Research

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Implication

Case-control study explores glycemic determinants in women with gestational diabetes, indicating immune-metabolic interactions.

Key Points

This research investigates the relationship between inflammatory cytokines, adipokines, and C-peptide with glycemic status in women with gestational diabetes.
Case-control design with 88 pregnant women (44 with GDM, 44 controls)
Measurement of fasting plasma glucose, C-peptide, interleukins (IL-6, IL-10, IL-13), and adipokines (chemerin, visfatin)
Spearman’s correlation and multiple linear regression analyses to determine associations
Women with GDM had higher fasting glucose and lower C-peptide levels than controls (p < 0.05)
Fasting glucose negatively correlated with IL-6 and C-peptide, and positively with chemerin
IL-6 and C-peptide were independent negative predictors of fasting glucose in regression analysis
Higher chemerin levels increased odds of GDM (OR = 1.010), while higher C-peptide (OR = 0.672) and IL-6 (OR = 0.796) decreased odds.

Cite This Study

Tiwary et al. (2026) studied this question.

synapsesocial.com/papers/69cd7ad45652765b073a842e https://doi.org/10.7759/cureus.106164

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Association Between Insulin Resistance Markers and Immunological Markers in Gestational Diabetes Mellitus

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Cite This Study

Association Between Insulin Resistance Markers and Immunological Markers in Gestational Diabetes Mellitus

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Implication

Key Points

Cite This Study

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