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October 1, 2025Open Access

Supplementary Figure 5 from Endoglin-Directed CAR T Cells Comprehensively Target Tumors in Advanced Sarcomas

Harrison R. Berger Malina Maharana Jeneffer Mirabal Lyazat Kurenbekova Alberto Delaidelli Atreyi Dasgupta Ahmed Z. Gad Mohamed F. Sheha Sybrina S. Kerr Ada I. Ozcan Jessica S. Morris Angela M. Major John Hicks Mary K. McKenna Ben K. Seon Matthew L. Baker Poul H. Sorensen Meenakshi Hegde Jason T. Yustein Nabil Ahmed Sujith K. Joseph

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Key Points

ENG CAR-T cells effectively target and reduce tumor size in advanced sarcoma models, showing potential as a new treatment option.
In orthotopic xenograft models, the ENG CAR-T cells demonstrated significant tumor reduction, indicating their strong efficacy.
This analysis utilized orthotopic xenograft models to assess the impact of ENG CAR-T cells on tumor growth and response.
These findings support the need for further investigation into CAR-T cell therapy, particularly for advanced sarcoma.

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Implication

Analysis reveals enhanced efficacy of ENG CAR-T targeting tumors in sarcoma models, suggesting potential treatment improvements.

Abstract

Efficacy of ENG CAR-T in orthotopic xenograft models of sarcoma.

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Cite This Study

Berger et al. (2025) studied this question.

synapsesocial.com/papers/68e040f7a99c246f578b3d33 https://doi.org/10.1158/2326-6066.30255002

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 4 from Endoglin-Directed CAR T Cells Comprehensively Target Tumors in Advanced Sarcomas2025
2Supplementary Figure 3 from Endoglin-Directed CAR T Cells Comprehensively Target Tumors in Advanced Sarcomas2025
3Data from Endoglin-Directed CAR T Cells Comprehensively Target Tumors in Advanced Sarcomas2025
4Supplementary Figure 6 from Endoglin-Directed CAR T Cells Comprehensively Target Tumors in Advanced Sarcomas2025
5Endoglin-directed CAR-T cells Comprehensively Target Tumors in Advanced Sarcomas2025 · 2 citations

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