Rethinking Pain Relief After Surgery

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Review demonstrates reduced opioid use with non-opioid medications for pain management in knee surgery, suggesting safer alternatives.

Non-opioid medications can effectively manage pain after surgery, lowering the reliance on opioids for recovery.
A recent RCT showed that 72% of patients on an opioid-sparing protocol remained opioid-free after knee surgery, compared to just 5.4% in the opioid group.
Analysis of 21 clinical trials suggests non-opioid options like NSAIDs and gabapentinoids can control pain with fewer side effects.
The findings indicate a significant opportunity to shift towards multimodal pain management, reducing unnecessary opioid prescriptions.

Asim Trimzi (2025) studied this question.

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