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October 5, 2025Open Access

Spinal cord structural and functional architecture and its shared organization with the brain across the adult lifespan

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Age-related changes were observed across spinal cord structure and function, indicating significant neural adaptations.
Notable changes occurred in the somatosensory pathway, with microstructural decline linked to altered functional connectivity.
Utilizing multimodal dataset, researchers mapped spinal cord architecture, revealing shared aging mechanisms with the brain.
Findings contribute to understanding sensorimotor decline, potentially aiding in developing early biomarkers for aging.

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Analysis reveals age-related changes in spinal cord structure and function in adults, suggesting shared CNS mechanisms.

Landelle et al. (2025) studied this question.

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