September 17, 2025Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition

Aging Causes Structural and Functional Reorganization of the Human Spinal Cord

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Authors

CLCaroline LandelleMontreal Neurological Institute and Hospital NKNawal KinanyUniversity of Geneva SSSamuelle St-OngeVanderbilt University

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Implication

This observational analysis shows age-related changes in spinal cord structure and connectivity in healthy adults, suggesting implications for sensorimotor functions.

Key Points

Significant reductions in gray-matter cross-sectional areas were observed in the cervical spinal cord among participants.
Functional connectivity analyses indicated reorganization of spinal cord networks, with increased dorso-ventral and decreased ventral connectivity.
Simultaneous cerebrospinal fMRI and spinal cord T2w data were utilized to assess structural and functional changes in 67 healthy individuals aged 20 to 80.
This work highlights the necessity of differentiating healthy aging from disease effects, potentially impacting clinical research and practices.

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Landelle et al. (2025) studied this question.

synapsesocial.com/papers/68d4597b31b076d99fa5cdfd https://doi.org/10.58530/2025/0654

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Implication

This observational analysis shows age-related changes in spinal cord structure and connectivity in healthy adults, suggesting implications for sensorimotor functions.

Aging Causes Structural and Functional Reorganization of the Human Spinal Cord

Discussion

Member takes

Implication

Key Points

Cite This Study

Aging Causes Structural and Functional Reorganization of the Human Spinal Cord

Discussion

Member takes

Implication

Key Points

Cite This Study

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