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October 3, 2025Open Access

Supplementary Figure S3 from AHRR DNA Methylation Levels in Leukocytes Identify People at Risk for Cancer Mortality Overlooked by Questionnaire-Based Smoking Indices

Yoshiki Tsuboi Hiroya Yamada Ryosuke Fujii Mirai Yamazaki Eiji Munetsuna Yoshitaka Ando Genki Mizuno Yuji Hattori Hiroshi Okumiyama Kensuke Murakami H Ishikawa Kyoichi Ohashi Koji Suzuki

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Key Points

Higher risk of cancer mortality identified through DNA methylation levels in leukocytes, highlighting genetic markers.
Adjusted hazard ratios suggest that common questionnaire-based smoking indices may overlook certain risks.
Analysis of leukocyte DNA methylation indicates that passive smoking factors contribute significantly to mortality risk.
The findings suggest that integrating molecular markers could improve cancer risk assessments in smokers.

Implication

Supplementary figure shows higher cancer mortality risk in smokers, indicating the relevance of DNA methylation adjustments.

Abstract

Supplementary Figure S3 shows HRs for each mortality stratified by PYs and AHRR DNAm after adjusting for passive smoking.

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Cite This Study

Tsuboi et al. (2025) studied this question.

synapsesocial.com/papers/68e24e65d6d66a53c2473511 https://doi.org/10.1158/1055-9965.30271446

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S5 from <i>AHRR</i> DNA Methylation Levels in Leukocytes Identify People at Risk for Cancer Mortality Overlooked by Questionnaire-Based Smoking Indices2025
2Supplementary Figure S1 from <i>AHRR</i> DNA Methylation Levels in Leukocytes Identify People at Risk for Cancer Mortality Overlooked by Questionnaire-Based Smoking Indices2025
3Supplementary Figure S4 from <i>AHRR</i> DNA Methylation Levels in Leukocytes Identify People at Risk for Cancer Mortality Overlooked by Questionnaire-Based Smoking Indices2025
4Supplementary Figure S2 from <i>AHRR</i> DNA Methylation Levels in Leukocytes Identify People at Risk for Cancer Mortality Overlooked by Questionnaire-Based Smoking Indices2025
5Data from <i>AHRR</i> DNA Methylation Levels in Leukocytes Identify People at Risk for Cancer Mortality Overlooked by Questionnaire-Based Smoking Indices2025

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