Supplementary Figure S5 from AHRR DNA Methylation Levels in Leukocytes Identify People at Risk for Cancer Mortality Overlooked by Questionnaire-Based Smoking Indices

Yoshiki Tsuboi; Hiroya Yamada; Ryosuke Fujii; Mirai Yamazaki; Eiji Munetsuna; Yoshitaka Ando; Genki Mizuno; Yuji Hattori; Hiroshi Okumiyama; Kensuke Murakami; H Ishikawa; Kyoichi Ohashi; Koji Suzuki

doi:10.1158/1055-9965.30271437

October 3, 2025Open Access

Supplementary Figure S5 from AHRR DNA Methylation Levels in Leukocytes Identify People at Risk for Cancer Mortality Overlooked by Questionnaire-Based Smoking Indices

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Key Points

DNA methylation levels in leukocytes identify individuals at heightened cancer mortality risk, not captured by questionnaire-based smoking indices.
Hazard ratios for various causes of mortality were adjusted for passive smoking to establish more accurate cancer risk assessments.
The analysis employed a stratified approach based on both YSQ (Youth Smoking Questionnaire) and AHRR (Aryl Hydrocarbon Receptor Repressor) DNAm levels.
These findings may indicate the necessity for more refined screening methods to address cancer mortality risk appropriately.

Implication

Analysis reveals that DNA methylation levels can better identify cancer mortality risk in individuals, suggesting improved methods for risk assessment.

Abstract

Supplementary Figure S5 shows HRs for each cause of mortality stratified by YSQ and AHRR DNAm after adjusting for passive smoking.

Discussion

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Cite This Study

Tsuboi et al. (2025) studied this question.

synapsesocial.com/papers/68e24e65d6d66a53c24737c2 https://doi.org/10.1158/1055-9965.30271437

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Supplementary Figure S5 from AHRR DNA Methylation Levels in Leukocytes Identify People at Risk for Cancer Mortality Overlooked by Questionnaire-Based Smoking Indices

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S5 from AHRR DNA Methylation Levels in Leukocytes Identify People at Risk for Cancer Mortality Overlooked by Questionnaire-Based Smoking Indices

Key Points

Implication

Abstract

Discussion

Cite This Study

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