Supplementary Methods and Tables from Late-Stage Outcomes as Surrogates for Mortality in Cancer Screening Trials: A Systematic Review and Meta-analysis

Supplementary Methods and Tables: includes five sections. Section 1 outlines the comparison with previously published meta-analyses of mortality outcome surrogacy in cancer screening trials (including Table S1 and Table S2, and description of this work). Section 2 outlines the systematic searches in bibliographic databases and study selection (including Tables S3-S11 and description of this work). Section 3 provides detailed information on trials and the reported outcomes for the assessment of mortality outcome surrogacy (including Table S12-15, and a reference list for those four tables). Section 4 details the detailed meta-analytic results, including sensitivity and subgroup analyses (Including the methods that surround Figures S1-4, Table S16, Table S17). Section 5 includes selected aspects of limitations in the reported trial data (Table S19 and a description of this work).