Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 5, 2025Open Access

Proteomic Insights into Strong and Weak Biofilm Formation in Acinetobacter baumannii for Potential Therapeutic Targets

View Full Paper
Ask AI
Bookmark
Share

Authors

VBVasundhra BhandariGovernment of IndiaUBUmarani BrahmaNational Institute of Pharmaceutical Education and ResearchASAkash SureshNational Institute for Interdisciplinary Science and Technology

Discussion

Loading...

Member takes

Implication

Comparative proteomic analysis revealed differential protein regulation affecting biofilm formation in Acinetobacter baumannii, indicating potential therapeutic targets.

Key Points

  • Proteomic profiling identified 42 proteins linked to strong biofilm formation in Acinetobacter baumannii, revealing dynamic cellular reprogramming.
  • Strong biofilm forming isolates showed significant upregulation of proteins like nlpA and DNA gyrase B, while downregulation was noted in stress-related factors.
  • The study utilized comparative proteomic profiling and correlated findings with qPCR to explore unknown regulators of biofilm formation.
  • Potential therapeutic targets identified include nlpA and DNA gyrase B, highlighting novel factors in biofilm regulation and resistance mechanisms.

Cite This Study

Bhandari et al. (2025) studied this question.

synapsesocial.com/papers/68e24e6fd6d66a53c2473e7ahttps://doi.org/10.1101/2025.10.02.680171
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Glycerol metabolism impacts biofilm phenotypes and virulence in Pseudomonas aeruginosa via the Entner-Doudoroff pathway2024 · 14 citations
  2. 2The proline-rich antimicrobial peptide Api137 disrupts large ribosomal subunit assembly and induces misfolding2025 · 15 citations
  3. 3Expression of Two Escherichia coli Acetyl-CoA Carboxylase Subunits Is Autoregulated2004 · 71 citations
  4. 4Purification, crystallization and preliminary crystallographic analysis of 3-hydroxyacyl-CoA dehydrogenase fromCaenorhabditis elegans2013 · 2 citations
  5. 5Discovery of Two Brominated Oxindole Alkaloids as Staphylococcal DNA Gyrase and Pyruvate Kinase Inhibitors via Inverse Virtual Screening2020 · 46 citations